Further testing led to the identification of the SARS-CoV-2 genotype. Analysis revealed 46 mutations and 37 deletions resulting in 30 amino acid substitutions and 12 deletions. Fourteen amino acid substitutions, including N501Y and E484K, and 9 deletions are located in the spike protein.
“This genotype model led to the creation of a new Pangolin line named B.1.640.2, which is a phylogenetic sibling group of the old B.1.640 line renamed B.1.640.1. The two lines differ in 25 nucleotide substitutions and 33 deletions. ” says the study.
âThe set of mutations and the phylogenetic position of the genomes obtained here indicate, based on our previous definition, a new variant that we named ‘IHU’,â said Colson.
He added that the data is “another example of the unpredictability of the emergence of SARS-CoV-2 variants.”
“Taken together, these observations once again show the unpredictability of the emergence of new variants of SARS-CoV-2 and their introduction from abroad, and they illustrate the difficulty of controlling such an introduction and its occurrence. subsequent spread, âColson said.
âSARS-CoV-2 variants have become of major virological, epidemiological and clinical concern, particularly with regard to the risk of evading vaccine-induced immunity. The emergence of the new variant justifies increased genomic surveillance of SARS-CoV-2, “he said.